ea0013s72 | Nuclear hormone receptor-chromatin interactions: new approaches and insight into dynamics | SFEBES2007
Carroll Jason
, Liu Shirley
, Li Wei
, Meyer Cliff
, Song Jun
, Brown Myles
Estrogen Receptor (ER) regulation of target gene transcription is a significant factor in tumor development and progression. Previous work on ER-mediated transcription focused primarily on promoter regions of target genes, although recent work from our lab combining ER Chromatin Immunoprecipitation (ChIP) with tiled microarrays covering chromosomes 21 and 22, showed that distal enhancers appear to be the primary ER binding sites, and that these sites require the Forkhead prote...